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Further studies have found that P53 can inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4 and resulting in the reduction of antioxidant capacity, ROS accumulation, and ferroptosis 11

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CBS overexpression in yeast and H 2 S production in HepG2 cells (Ostrakhovitch et al., 2002

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